Fig. 1

Spatially adaptive representation of images. a Example image of fluorescently labeled zebrafish cell nuclei (exemplar dataset 7, courtesy of Huisken Lab, MPI-CBG & Morgridge Institute for Research²⁵), represented on a regular grid of pixels. b The APR of the same image. Particles are shown as dots with their color indicating fluorescence intensity and their size reflecting the local resolution of the representation. c–f Adaptively representing objects of different intensity requires accounting for the local brightness levels. c Two regions of labeled cell nuclei (exemplar dataset 6, courtesy of Tomancak Lab, MPI-CBG) with different brightnesses. d Adaptive representation based on the absolute intensity. f The APR accounting for the Local Intensity Scale of the image as shown in e. In f, all objects are correctly resolved across brightness levels. Scale bars indicate 10 pixels