Table 1 The intercept k of the boundary of the depleted region varies over two orders of magnitude across the studied organisms

From: Central dogma rates and the trade-off between precision and economy in gene expression

Organism

Measured k

Predicted k

\(\beta _p^{{\rm{max}}}\left( { \times 10^3} \right)\)

α p

\({\sum} {\kern 1pt} \beta _m\left( { \times 10^4} \right)\)

c v0

S. cerevisiae

1.1 ± 0.1

1.1 ± 0.3

7.1 ± 0.7

1.3 ± 0.2

30 ± 15

0.10 ± 0.01

E. coli

14 ± 3

13 ± 4

11 ± 1

1.9 ± 0.3

2.0 ± 1

0.25 ± 0.01

M. musculus (3T3)

44 ± 3

29 ± 8

3.0 ± 0.3

0.04 ± 0.01

2.5 ± 1.2

0.3 ± 0.03

H. sapiens (HeLa)

66 ± 4

60 ± 17

5.1 ± 0.5

0.05 ± 0.01

1.4 ± 0.7

0.3 ± 0.03

  1. k can be predicted from the maximal translation rate \(\beta _p^{{\rm{max}}}\) [protein mRNA−1h −1], the protein decay rate αp [h−1], the total transcriptional output \({\sum} {\kern 1pt} \beta _m\) [mRNA h−1], and the noise floor cv0 using Eq. (5). The measured k is defined by having 99% of genes with βp/βm > k. Uncertainties represent standard errors determined from 3744 to 9770 genes depending on the organism
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