Fig. 4 | Nature Communications

Fig. 4

From: Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

Fig. 4

Cryo-EM structure of CMG-Pol epsilon. a Diagram of the reconstitution of CMG-Pol epsilon on a pre-formed fork. CMG stands for Cdc45-MCM-GINS. b Silver-stained SDS-PAGE gel of the reconstituted CMG-Pol epsilon-DNA complex. c Two-dimensional class averages of the CMG-Pol epsilon-DNA complex. d Cryo-EM structure of CMG-Pol epsilon with docked/real-space refined homology models of CMG and C-Pol2/Dpb2 components

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