Fig. 8
BMP8b-dependent signaling proteins involved in vegfa and nrg4 regulation. a, b BMP8-induced phosphorylation state fold change of signaling proteins ordered by network distance to the transcription factors regulating vegfa (a) and nrg4 (b). Bars show the fold changes of the most affected phosphorylation site on each protein, 1 corresponding to no change while, for example, 2 meaning the proportion of phosphorylate proteins doubled upon BMP8 treatment. The top line shows the log scale proximity of the signaling proteins to the transcription factors, from the closest on the left, distance increases to the right. c Estimated activities of transcription factors regulating vegfa in BAT from 5-week-old bmp8b TG mice estimated from expression data. Positive and negative values correspond to up-regulated and down-regulated TFs, respectively. Ordered by p value from the lowest on the left, showing only p value < 0.2
