Fig. 3 | Nature Communications

Fig. 3

From: Genome-wide association meta-analysis yields 20 loci associated with gallstone disease

Fig. 3

SLC10A2 transport activity and gallstone risk. a Schematic illustration of the topology of the SLC10A2 protein showing the localization of the functionally assessed missense variants Pro290Ser, Val98Ile, Val159Ile, and Ser171Ala (from PMID: 19823678). b A scatter plot showing four SLC10A2 missense variants Pro290Ser, Val98Ile, Val159Ile, and Ser171Ala. The x-axis shows the bile acid transport activity (from PMID:21649730) while the y-axis shows the odds ratio for gallstone disease in the Iceland + UK meta-analysis (Ncases = 27,174, Ncontrols = 736,838)

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