Fig. 2 | Nature Communications

Fig. 2

From: Cobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides

Fig. 2

Cobalt-catalyzed difluoroalkylation of aryl ketones. a Scope of cyclic ketones. b Scope of acyclic ketones. c Scope of difluoroalkylating reagents. Conditions: 1 (0.2 mmol, 1.0 equiv), 2 (3.0 equiv), CoBr2 (10 mol%), dppBz (10 mol%), LDA (105 mol%), Zn (0.5 equiv), THF (2.0 mL), −10 °C, 12 h, under N2 atmosphere. aConditions: 20 mol% of CoBr2 and 20 mol% of dppBz were used. dppBz = 1,2-bis(diphenylphosphino)benzene

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