Fig. 2
Chemical and crystal structure of (Ra)-7. a Crystal structure of (Ra)-7 in complex with Mcl-1. Note coplanar alignment of Arg 263 and the carboxylic acid and the interaction between 17-Cl of (Ra)-7 and the backbone carbonyl of Ala227 (pdb id: 6FS0). The protein surface around the highlighted residues has been hidden for clarity. b Structure of (Ra)-7 and numbering of atoms. c 1H NMR of (Ra)-7, highlighting the upfield chemical shift of H38 indicative of a conformation that is rigid and consistent with the active binding conformation depicted in a
