Table 2 TR-FRET assay-binding parameters of Bim or Bak peptides to Bcl-2 pro-survival proteins used in Ki calculations

From: Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

  

Peptide, Kd (nM)

Peptide conc. (nM)

Mcl-1

Hylite Bim peptide

1.5

4

Bcl-xL

Hylite Bak peptide

10

10

Bcl-2

Biotin Bim peptide(biotin-Ic-)

5

10

Bcl-w

Biotin Bim peptide(biotin-Ic-)

10

10

Bfl-1

Hylite Bim peptide

10

10

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