Fig. 2
From: Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
Cardiac-specific deletion of PRMT1 results in reduced cardiac function and increased mass. a The short axis transthoracic M mode echocardiographic tracings from 7-weeks-old f/f and cKO mice. b–i Echocardiographic parameters. IVS;d the interventricular septum;diastolic, LVID;d or LVID;s the internal dimension of left ventricle (LV); diastolic or systolic, LVPW;d or LVPW;sthe postwall thickness of LV; diastolic or systolic. EF the ejection fraction, FS the fraction shortening, LV Mass Left ventricular mass (n = 7–10 per group). Data represent means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, Student’s t-test. j A representative ECG recording of spontaneous bradycardia in 7-weeks-old cKO and a normal ECG recording in f/f littermate. k Bar plots of heart rate and EKG intervals in f/f and cKO mice show the decreased heart rate and the prolonged QT interval in cKO mice. Data represent means ± SEM. *P < 0.05, Student’s t-test
