Fig. 2
From: Modeling genome-wide enzyme evolution predicts strong epistasis underlying catalytic turnover rates
Evolutionary trajectories exhibit convergence and diminishing returns epistasis. a The growth rate of the population against the number of simulated mutations. The black line shows the average growth rate across replicates and its standard error. The replicates showed 4880 fixation events on average. See Supplementary Figure 3 for a fit of the analytical model presented in Supplementary Note 1. b The selection coefficient s (defined as the change in growth rate relative to the novel growth rate) plotted against the cumulative number of simulated mutational events for all fixed mutations. The inset shows s against the background growth rate in which a mutation occurred for the three reactions that had the most changes in kcat fixed. These reactions are: ATPS4rpp: ATP synthase (orange), GLUDy: Glutamate dehydrogenase (NADP) (green), and PPC: Phosphoenolpyruvate carboxylase (blue)
