Fig. 2 | Nature Communications

Fig. 2

From: Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors

Fig. 2

Approach used for interpreting miRNA-target interactions. a First, miRNA-target pairs for each positively associated hallmark-associated miRNA were identified, and the correlation between these was determined. b Next, the correlations across cancer types were aggregated, and those identified as consistently negative-ranking were identified with the rank product statistic. c Among this list of miRNA-mRNA target pairs, there was highly significant enrichment for tumour suppressor genes, as identified by the Fisher exact test. d The same procedure as described in a and b was repeated for all miRNA and all predicted target TSG pairs, with each TSG considered individually. e From the lists identified in b and d, we identified those miRNA-TSG pairs in common, and plot their interactions on a circos plot, showing the repressive actions of each miRNA on its predicted target TSG

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