Fig. 4
From: Drug and disease signature integration identifies synergistic combinations in glioblastoma
L1000 consensus signatures reflect molecule mechanism of action. a Correlation matrix of the 285 LINCS consensus signatures and the 14 GBM consensus signatures. The LINCS L1000 dataset was merged with the GBM L1000 dataset, and TCSs were calculated and used to produce the correlation matrix. The red clusters along the diagonal indicate compounds that have highly correlated consensus signatures. b Networks of highly correlated LINCS small molecules. A connection indicates a 0.7 or above Pearson correlation of their consensus gene signatures. The compounds were colored and labeled based on their mechanism of action as identified through a literature search. Compound names and mechanisms of action can be found in Supplementary Figure 3
