Table 1 Top 10 upregulated (top) and top 10 downregulated (bottom) L1000 genes with expression levels from mechanism of action networks in Fig. 4

BET		mTOR/PI3K		CDK		HDAC		HSP90		MEK
PNKP	9.29	NPDC1	9.69	PAK1	11.67	PRCP	10.4	SMNDC1	10.75	HSPB1	10
SLC25A4	9	MAP2K5	9.88	CAMSAP2	11.78	MNAT1	10.6	SPAG7	11.25	HMOX1	8.33
CPNE3	9.14	FOXO4	9.44	TBXA2R	11.89	PTPN1	10.4	NUDT9	11.5	ECH1	7.5
STUB1	8.71	MBTPS1	9.63	MAPK9	12.56	FOXO4	10.4	HSPD1	11.75	TSC22D3	7.17
AKR7A2	9.14	HSD17B11	9.38	TCEA2	12.56	TCEA2	10.4	SNX6	11	NFIL3	9.17
BNIP3L	8.57	CBLB	9.38	SOCS2	11.56	IER3	11.2	HSPA8	12	PIK3R3	7.17
STXBP1	10.29	CDK19	9.75	NFKBIE	12	RRAGA	9.8	KIAA0494	12	PPIC	7.83
CIRBP	8.14	SNCA	11.19	ADAT1	12.11	LIPA	10.8	ATP2C1	12	NNT	8
TMEM2	8.29	KLHDC2	11.25	RAB27A	11.89	ANO10	10	PRUNE	11.75	NFKBIA	7.17
LRPAP1	8.29	POLD4	11.06	GPC1	12.89	SSBP2	9.8	ARID4B	11	BRP44	8.17
DECR1	−7.29	CYCS	−11.38	COPB2	−10.89	PUF60	−11.8	SLC37A4	−11.75	STX1A	−9.83
ATF1	−6.86	GTF2A2	−11.38	CDC25B	−11.11	SUV39H1	−13.4	TSEN2	−10.75	DUSP6	−10.67
TMEM109	−8	BIRC5	−10.06	KIAA0528	−12	ADI1	−13	CETN3	−10.75	DUSP4	−8.83
CRYZ	−7	ICMT	−9.94	PCM1	−11.33	TIMELESS	−11.6	TIPARP	−11.25	EGR1	−10.67
IKBKE	−7	MYBL2	−9.88	ATF1	−11.67	PFKL	−11.6	NUP88	−11.75	CCND1	−8.83
ICAM3	−7.86	PGAM1	−10.69	CASC3	−11.67	MICALL1	−11.6	PXMP2	−11.25	SPRED2	−8.33
PYCR1	−9.86	MYCBP	−10.19	SCAND1	−11	NUP85	−11.8	IER3	−11	FOSL1	−9.5
SORBS3	−8	PHGDH	−10.13	ADAM10	−12.22	AKAP8	−11.6	PAFAH1B3	−12	ITGB5	−10.33
PSMB8	−7.43	RUVBL1	−9.88	CLTC	−11.78	DCTD	−11.6	CCDC85B	−13.25	MAT2A	−7.17
PLOD3	−8.86	POP4	−11.13	ATMIN	−11.56	KEAP1	−13.4	AMDHD2	−12.25	HMGA2	−8.5

Quick links

Search