Fig. 1
From: Role of NS1 antibodies in the pathogenesis of acute secondary dengue infection
Kinetics of DENV NS1-specific antibody responses in acute dengue. a NS1 antibody levels in patients with past severe dengue (SD) (n = 34), non-severe dengue (NSD) (n = 36) and dengue seronegatives (n = 20). b DENV1 NS1-specific IgG antibody levels, measured in patients with an acute secondary DENV1 infection causing DF (n = 10) or DHF (n = 10) using ELISA. c DENV2 NS1-specific IgG antibody levels were measured in patients with an acute secondary DENV2 infection causing DF (n = 12) or DHF (n = 23) using ELISA. DENV-specific IgM antibody (Panbio unit) in patients with an acute secondary DENV1 (d) and DENV2 (e). DENV-specific IgG antibody levels were measured in patients with an acute DENV1 (f) and DENV2 (g) infection. Differences between serial values of NS1-specific antibodies and IgM and IgG in patients with DHF and DF were compared using the Holm–Sidak method. The vertical dotted line represents the day in which the patients entered the critical phase. NS1 antibody levels in patients with DHF are indicated in red, and in those with DF in blue. Error bars indicate mean and standard error of mean (SEM). *P < 0.05, **P < 0.01
