Fig. 2
The largest cluster comprises 40 phenotypes related to fat metabolism. a SNPs associated with inflammatory bowel disease, cholesterol levels, insulin sensitivity, muscle strength index and laryngeal squamous cell carcinoma, amongst others, are associated with transcription effects at a pool of shared spatial eGenes. Deep blue squares indicate higher proportions of shared eGenes, with 1 being the highest and indicating that two phenotypes have the same set of eGenes. b The FADS locus on chromosome 11 is responsible for the identified interrelationships (i.e. the multimorbidity) between the phenotypes in this cluster. We hypothesise that the interrelationships between the additional 2431 spatial eGenes that are associated with these multimorbid phenotypes contribute to the unique characteristics and sub-clustering of the phenotypes (Supplementary Data 4). In this word cloud, the size of a gene name represent the percentage of phenotypes whose associated variants spatially affect the expression of that gene in the cluster e.g. the expression of FADS1, FADS2 and TMEM258 are associated with eQTLs in 26 of the 40 phenotypes in the cluster (Supplementary Data 4)
