Fig. 4 | Nature Communications

Fig. 4

From: Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities

Fig. 4

eQTLs have different effect patterns within the fat metabolism cluster. Spatial eQTLs have tissue-specific and LD-dependent effects on genes in the FADS cluster. There is also an inverse association between the eQTL effects on FADS1 and FADS2. rs174574, rs422249, rs174448, rs174449, and rs100078 are associated with an increase in FADS1 and decrease in FADS2 transcript levels. All other eQTLs are associated with a decrease in FADS1 and increase in FADS2 transcript levels. Effect sizes of spatial eQTL on eGenes were obtained from GTEx v7

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