Fig. 7
Schematic model of gene pleiotropy in multimorbidities. a Common target genes between any two complex disorders highlight the molecular mechanism(s) that underlie their common pathogenicity. The sets of target genes that are unique to the disorders represent the mechanisms that make the disorders different. Gene pleiotropy in multimorbidities of complex disorders can occur when b a variant associated with the disorders marks a regulatory element that target the common gene; c different variants associated with different disorders mark the same (super)-regulatory element that impacts the common gene; or d different regulatory elements marked by different variants impact the common gene
