Table 2 Analysis of the asymmetric hydrogenation of N-methyl-1-phenylethan-1-imine
| |||||||||
|---|---|---|---|---|---|---|---|---|---|
Entry | Reaction conditions | Traditional analysisa | Chiroptical sensingb | ||||||
Ligand | Cat. load. (mol%) | Time (h) | Abs. config. | % ee | Conv. | Abs. Config. | % ee | Conv. | |
1 | 49 | 5.00 | 18 | S | 55.8 | 99.9 | S | 59.8 | 96.0 |
2 | 50 | 5.00 | 18 | R | 16.3 | 99.9 | R | 14.3 | 99.9 |
3 | 51 | 5.00 | 18 | R | 31.0 | 99.9 | R | 32.2 | 99.1 |
4 | 52 | 5.00 | 18 | R | 31.4 | 99.9 | R | 25.8 | 98.0 |
5 | 53 | 5.00 | 18 | S | 16.3 | 92.0 | S | 14.2 | 96.3 |
6 | 49 | 2.50 | 1 | S | 46.2 | 51.1 | S | 47.8 | 53.9 |
7 | 49 | 3.25 | 1 | S | 57.3 | 63.3 | S | 54.5 | 68.4 |
