Table 1 Inhibition of C. difficile toxin-induced cytotoxicity by niclosamide and NEN

From: Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

 

TcdB012

TcdB078

TcdB027

TcdA

CDT

Niclosamide IC50 (μM)

0.44 ± 0.05

0.5 ± 0.2

0.4 ± 0.1

0.5 ± 0.1

0.53 ± 0.08

NEN IC50 (μM)

0.43 ± 0.03

0.45 ± 0.09

0.5 ± 0.1

0.55 ± 0.08

0.50 ± 0.09

  1. The data are expressed as the means ± s.e.m.
  2. Niclosamide replicates: TcdB012, n = 8; TcdB078, n = 4; TcdB027, n = 4; TcdA, n = 6; CDT, n = 4
  3. NEN replicates: TcdB012, n = 7; TcdB078, n = 4; TcdB027, n = 3; TcdA, n = 4; CDT, n = 3
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