Table 1 Overview of the IMEx mutations data set downloadable flat file

Feature AC	Feature short label	Feature range(s)	Original sequence	Resulting sequence	Feature type	Feature annotations	Affected protein AC & details^a	Interaction participants & details^a
EBI-10828532	p.Arg725Glu	725–725	R	E	mutation(MI:0118)	MI:0612 (comment): Disrupts association with VPS33A and decreases association of VPS18	See Supplementary Table 1	See Supplementary Table 1
EBI-985220	p.Ile114Gly	114–114	I	G	mutation increasing(MI:0382)		“	“
EBI-4370347	p.[Asn31His;Ala60Val]	31–31	D	H	mutation increasing(MI:0382)	- (kd): 11e-9M	“	“
EBI-4370347	p.[Asn31His;Ala60Val]	60–60	A	V	mutation increasing(MI:0382)	- (kd): 11e-9M	“	“
EBI-10688294	p.Thr2Ala	2–2	T	A	mutation decreasing rate(MI:1130)		“	“
EBI-9635600	p.Cys_Ser215-216Ala_Ala	215–216	CS	AA	mutation disrupting(MI:0573)		“	“

Each mutation annotation is identified with a unique accession (‘Feature AC’) and is described with an HGVS-compliant short label (‘Feature short label’), plus sequence coordinates and amino acid replacement details (‘Feature range(s)’, ‘Original sequence’, ‘Resulting sequence’). The effect the mutation has on the interactions is listed using the PSI-MI controlled vocabulary (‘Feature type’). Each line in the file represents a single continuous section of sequence affected, with mutations spread in multiple positions represented in several lines and sharing the same ‘Feature AC’. Annotations for complex effects that cannot be captured via PSI-MI CV and kinetic parameters are also recorded when available (‘Feature annotations’). ^aThese are placeholders for additional columns containing information about the affected proteins and interactions. These are available in the fully expanded version of this table in Supplementary Table 1

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