Fig. 1 | Nature Communications

Fig. 1

From: Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development

Fig. 1

TF binding and zygotic genome activation. a Sketch of zygotic mRNA levels as a function of embryo stage. Inset: schemes of embryos at different developmental stages. b Scheme of TF binding to chromatin: free TFs associate with rate constant kon to and dissociate with rate constant koff from an apparent number of chromatin binding sites D0. The concentrations of all species involved depend on their quantities and the nuclear volume Vn. Inset: formula describing the chromatin-bound fraction of TFs that does not depend on the concentration of TFs

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