Fig. 3
LPS-primed Nlrp12-deficient mice are highly susceptible to secondary challenge by bacterial MDP. a The survival of wild-type mice (n = 8) and Nlrp12−/− mice (n = 7) was plotted after i.p. administration of a lethal dose of ultrapure LPS from E. coli 0111:B4 (54 mg/kg). b The survival of wild-type mice (n = 18) and Nlrp12-deficient mice (n = 9) was plotted after a non-lethal dose of ultrapure LPS from E. coli 0111:B4 (10 mg/kg) that was followed 24 h later with i.p. Murabutide administration at 10 mg/kg. c The survival of wild-type mice (n = 8), Nlrp12−/− mice (n = 7) and compound mutant mice (n = 8) was plotted after a non-lethal dose of ultrapure LPS from E. coli 0111:B4 (2 mg/kg) that was followed 24 h later with i.p. Murabutide administration at 10 mg/kg. P-value by log-rank test
