Fig. 3

Neuronal activity in the beta frequency range is normalized in the CeM of double KO mice. a Representative image of the location of electrode in the CeM and experimental design. Scale bar, 500 µm. After electrode implantation mice were exposed to the OF for 15 min. b Representative traces of CeM LFPs from all four genotypes during SAP. c, d LFP power spectrum for all four genotypes during movement in the periphery (c) and center (d) of the OF. e Average power increase in the center relative to the periphery of the OF for the beta frequency range (18–30 Hz). f–i Increase in normalized beta power as a function of distance from the center in WT (f), Nlgn2 KO (g), IgSF9b KO (h), and double KO (i) mice. Statistical analysis of correlations is indicated in the figure. j Schematic of the stretch-attend posture (SAP) scored during the OF test. k Representative wavelet transforms of CeM LFP of the four genotypes during exploration of the OF. White horizontal lines indicate the duration of a representative SAP. l Average beta power during SAP. Statistically significant ANOVA comparisons are marked in gray at the top of the panels and are listed in Table 1. For all other ANOVA comparisons, F < 1. Post-hoc analysis: *p < 0.05 relative to WT, ***p < 0.001 relative to WT, ^#p < 0.05 relative to double KO, ^##p < 0.01 relative to double KO, ^###p < 0.001 relative to double KO. SAPs and mice: WT n = 77/ 6 mice; Nlgn2 KO n = 62/ 5 mice; IgSF9b KO n = 84/ 6 mice; double KO n = 71/ 5 mice. Error bars represent SEM. WT, white bars; Nlgn2 KO, red bars; IgSF9b KO, blue bars; double KO, purple bars