Fig. 5 | Nature Communications

Fig. 5

From: HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity

Fig. 5The alternative text for this image may have been generated using AI.

Functional and dysregulated checkpoints of RIG-I proofreading. a Schematic representations of functional RIG-I checkpoints governing RIG-I CARDs conformational transition. b Schematic representations of aberrant CARDs conformational transition of RIG-I gain-of-function mutants revealed by comprehensive differential HDX analysis with quantitative analysis of CARDs EX1 exchange kinetics

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