Fig. 1

miR-122 has a consistent degradation pattern but remains expressed from a subset of cells. a Percentage of small RNA-seq reads that map to miR-122 relative to all other microRNAs in livers of miR-122 floxed mice at various time points after receiving 1×10¹² vector genomes of rAAV8-Cre (n = 1 mouse per point on the graph). b Relative abundance of main isoforms of miR-122-5p from small RNA-seq data (n = 3 mice for days 0, 7, 14, 21, and 45, error bars are s.e.m.; n = 1 for the remaining timepoints). c Small RNA northern blot of miR-122 expression in mouse livers at various timepoints after miR-122 excision. d Quantification of bands from c. e Proportion of rare miR-122-5p isoforms relative to all mapped microRNAs. f Schematic of the processing of miR-122-5p isoforms. g Percentage of miR-122 relative to all microRNAs at longer time periods after miR-122 removal and in mice expressing Cre under the Albumin promoter leading to a liver-specific knockout of miR-122 (LKO) (n = 3 for days 0 and 200, n = 2 for LKO and LKO + Cre and n = 1 for day 100). h miR-122-5p isoform distributions of samples from g