Fig. 4
From: Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides
Anti-Wolbachia potency and drug-like properties of six cluster representatives. Nine hit series were categorised based on the balance between potency in the microfilarial assay and drug metabolism and pharmacokinetic (DMPK) properties. The figure shows the best representatives of the top six clusters. Five axes in the radar plots represent: EC50 values (nM) in the anti-Wolbachia microfilarial assay (MF), rat hepatocytes clearance (µl min−1 1 × 106 cells−1) (Rat Heps), human microsome clearance (µl min−1 mg−1) (Hum Mics), LogD7.4 (LogD) and log value of aqueous solubility in pH 7.4 PBS buffer (µM) (LogS). The core of each cluster chemotype is highlighted blue within the chemical structures
