Table 1 Average percentage of variants in on-target and off-target sites
Target Site | Time after treatment | Group | ONT | OFT1 | OFT2 | OFT3 | OFT4 | OFT5 | OFT6 | OFT7 |
|---|---|---|---|---|---|---|---|---|---|---|
Hao1-g1 | 4 weeks | Saline (n = 1) | 0.14 | 0.12 | 0.1 | 0.03 | 0.08 | 0.01 | 0.26 | 0.11 |
Cas9 (n = 3) | 0.18 | 0.17 | 0.09 | 0.06 | 0.08 | 0.04 | 0.3 | 0.08 | ||
Hao1-g1 (n = 5) | 48.46 | 0.18 | 0.08 | 0.05 | 0.08 | 0.04 | 0.29 | 0.08 | ||
6 months | Saline (n = 1) | 0.14 | 0.12 | 0.1 | 0.03 | 0.08 | 0.01 | 0.26 | 0.11 | |
Cas9 (n = 3) | 0.24 | 0.18 | 0.07 | 0.06 | 0.07 | 0.04 | 0.28 | 0.07 | ||
Hao1-g1 (n = 5) | 60.57 | 0.19 | 0.08 | 0.05 | 0.07 | 0.03 | 0.32 | 0.1 | ||
Hao1-g2 | 4 weeks | Saline (n = 1) | 0.14 | 0.12 | 0.1 | 0.03 | 0.08 | 0.01 | 0.26 | 0.11 |
Cas9 (n = 3) | 0.08 | 0.07 | 0.09 | 0.09 | 0.06 | 0.07 | 0.1 | 0.11 | ||
Hao1-g2 (n = 5) | 52.81 | 0.08 | 0.09 | 0.08 | 0.06 | 0.06 | 0.13 | 0.11 | ||
6 months | Saline (n = 1) | 0.14 | 0.12 | 0.1 | 0.03 | 0.08 | 0.01 | 0.26 | 0.11 | |
Cas9 (n = 3) | 0.08 | 0.07 | 0.09 | 0.1 | 0.08 | 0.06 | 0.11 | 0.12 | ||
Hao1-g2 (n = 5) | 60.13 | 0.07 | 0.08 | 0.08 | 0.07 | 0.07 | 0.1 | 0.12 |
