Fig. 4 | Nature Communications

Fig. 4

From: Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

Fig. 4

Two-sample MR of eGFR on diastolic blood pressure and hypertension. Results are presented separately for each component of the trans-ethnic meta-analysis for diastolic blood pressure (top) and essential (primary) hypertension (bottom). Each point corresponds to a lead SNV (instrumental variable) across 94 kidney function loci, plotted according to the MR effect size of eGFR on outcome (Wald ratio). Bars correspond to the standard errors of the effect sizes. The red point and bar in each plot represents the MR effect size of eGFR on outcome across all SNVs under inverse variance weighted regression. The p-values are obtained under inverse variance weighted regression. Results for other methods are presented in Supplementary Table 8

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