Table 1 Novel loci attaining genome-wide significant evidence (p < 5 × 10−8) of association with eGFR in trans-ethnic meta-analysis of up to 312,468 individuals of diverse ancestry

From: Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

Locus

Lead SNV

Chr

Position (bp, b37)

Alleles

EAF

Fixed-effects meta-analysis

Effecta

Other

p-value

N

Betab

SEb

PMF1-BGLAP

rs2842870

1

156,200,671

T

C

0.632

1.2 × 10−8

312,468

−0.361

0.094

NT5C1B-RDH14

rs13417750

2

18,681,365

A

G

0.189

1.0 × 10−8

312,468

−0.439

0.108

C2orf73

rs1527649

2

54,581,356

C

T

0.234

1.5 × 10−9

311,225

−0.413

0.107

ORC4

rs13026220

2

148,586,459

G

A

0.366

3.1 × 10−11

312,468

−0.265

0.095

NFE2L2

rs35955110

2

178,143,371

C

T

0.435

3.9 × 10−9

312,468

−0.353

0.099

XYLB

rs36070911

3

38,498,439

G

A

0.528

2.3 × 10−11

312,468

−0.296

0.091

AK125311

rs856563

7

46,723,510

C

T

0.750

5.1 × 10−10

309,287

−0.455

0.094

SHH

rs6971211

7

155,664,686

T

C

0.417

6.5 × 10−13

309,287

−0.350

0.090

NRG1

rs4489283

8

32,399,662

T

C

0.296

1.5 × 10−8

311,632

−0.325

0.094

TRIB1

rs2001945

8

126,477,978

C

G

0.546

1.6 × 10−9

312,468

−0.264

0.091

DCAF12

rs61237993

9

34,130,435

G

A

0.666

4.0 × 10−8

312,465

−0.345

0.122

MYPN

rs7475348

10

69,965,177

C

T

0.607

8.6 × 10−19

312,468

−0.366

0.095

CYP26A1

rs4418728

10

94,839,724

T

G

0.539

1.4 × 10−8

312,468

−0.345

0.092

FAM53B

rs4962691

10

126,424,137

T

C

0.571

5.0 × 10−10

312,468

−0.291

0.093

RASGRP1

rs9920185

15

39,273,575

C

A

0.649

1.0 × 10−8

312,468

−0.332

0.094

NFAT5

rs11641050

16

69,622,104

C

T

0.697

2.6 × 10−8

312,468

−0.283

0.099

JUND-LSM4

rs8108623

19

18,408,519

A

C

0.695

4.4 × 10−8

309,634

−0.390

0.108

ARFRP1

rs1758206

20

62,336,334

T

C

0.082

2.4 × 10−8

163,534

−0.546

0.193

NRIP1

rs2823139

21

16,576,783

A

G

0.293

3.7 × 10−9

311,637

−0.197

0.093

ATP50

rs2834317

21

35,356,706

A

G

0.108

9.5 × 10−10

312,468

−0.475

0.126

  1. Chr: chromosome, EAF: effect allele frequency, SE: standard error
  2. aEffect allele is aligned to be eGFR decreasing allele
  3. bBeta/SE are obtained from fixed-effects meta-analysis, with inverse variance weighting of allelic effect sizes, of up to 81,829 individuals of diverse ancestry from the COGENT-Kidney Consortium, and represent absolute decrease in eGFR (ml/min per 1.73m2) per effect allele
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