Fig. 8 | Nature Communications

Fig. 8

From: CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ

Fig. 8

A proposed model for the role of CKIP-1 in atherosclerosis. CKIP-1 regulates the formation of foam cells by coupling proteasome activator REGγ to target the transcription factor Oct-1 for degradation, thereby suppressing the transcription of LOX-1 and the macrophage lipid uptake. On the contrary, Ckip-1 deficiency results in the increased expression of LOX-1, facilitates uptake of oxLDL and accumulation of cholesterol within the cells, and further results in the promotion of atherosclerosis

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