Fig. 6
From: The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis
TOP1MT-KO gene expression signature and expression predict survival of HCC patients. a Supervised hierarchical clustering of gene expression profiles from 3 independent Top1mt-KO and WT mouse HCCs. b Integrative cluster analysis of murine HCCs applied to 53 human HCC patient samples using orthologous genes. Light blue bars indicate HCC patients with good survival prognosis, dark blue bars, HCC patients with poor survival, dark red bars, murine Top1mt-KO HCC, and black bars, murine HCC expressing Top1mt. c Overall survival of HCC patients based on the TOP1MT gene expression signature. d High expression of TOP1MT is associated with poor survival of patients with HCC (370 total cases from the TCGA database including 138 patients with high TOP1MT expression and 232 patients with low TOP1MT expression)
