Fig. 4
Aversion to high amounts of Z5–14:OH in both wild type and Olfr288 knockout mice. a Setup of the odor investigation assay. A mouse was exposed for 3 min to a filter paper bearing odorant placed in the middle of cage. The time the mouse spent investigating the odor source was measured. b Representative traces of wild type (WT) and Olfr288 knockout (KO) mice investigating 10 pg Z5–14:OH. c Odor investigation assay for various amounts of Z5–14:OH, intact or castrated urine, eugenol, or TMT, in adult female C57BL/6 mice (black bars) (N = 15) and adult female Olfr288-KO mice (red bars) (N = 10). Eugenol was diluted in mineral oil. TMT was diluted in PG. Z5: Z5–14:OH; oil: mineral oil; EG, eugenol; PG, propylene glycol. Data are means ± S.E.M. Mann–Whitney test: *P < 0.05, **P < 0.01, ***P < 0.001
