Fig. 5

Distribution of metabolic interaction types. a Schematic representation of interaction types arising from costlessly secreted metabolites. Competition is defined as both organisms consuming the same carbon source. Commensalism is defined as a unidirectional exchange of one or more costlessly secreted metabolites, and mutualism is defined as a bidirectional exchange of one or more costlessly secreted metabolites. b Overall distributions of competitive and non-competitive interactions for oxic (out of 164,939 simulations that yielded pairwise growth) and anoxic conditions (out of 115,463 simulations that yielded pairwise growth). c Overall distributions of general interactions mediated by costless metabolites for oxic and anoxic conditions. These interactions at the level of secreted metabolites exist simultaneously with competition or no competition for a primary carbon source. d Organism-specific growth outcomes and interaction type distributions. Size of circles represent the relative number of environments in which an organism was able to grow out of 5774 in silico experiments with each partner. BS: B. subtilis, EC: E. coli, KP: K. pneumoniae, LL: L. lactis, ME: M. extorquens, PA: P. aeruginosa, PG: P. gingivalis, RS: R. sphaeroides, SB: S. boydii, SC: S. cerevisiae, SE: S. enterica, SO: S. oneidensis, SS: Synechocystis, ZM: Z. mobilis