Fig. 4

Interaction of rs141588480 in SNTA1 with physical activity on HDL cholesterol levels. The beta and 95% confidence intervals in the forest plot (a) is shown for the rs141588480 × physical activity interaction term, i.e., it indicates the increase in logarithmically transformed HDL cholesterol levels in the active group as compared to the inactive group per each insertion of rs141588480. The –log₁₀ (p value) in the association plot (b) is also shown for the rs141588480 × physical activity interaction term. While the rs141588480 variant was identified in African-ancestry individuals in Stage 1, the variant did not pass QC filters in the Stage 2 African-ancestry cohorts, due to insufficient sample sizes of these cohorts. The P values are two-sided and were obtained by a meta-analysis of linear regression model results. The figure was generated using LocusZoom (http://locuszoom.org)