Table 1 Lipid loci identified through interaction with physical activity (PINT < 5 × 10−8) or through joint test for SNP main effect and SNP × physical activity interaction (PJOINT < 5 × 10−8)

From: Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Trait

SNP

Chr:Pos

Gene

EA/OA

EAF

N inactive

N active

BetaINT

seINT

P INT

P JOINT

Loci identified through interaction with physical activity

 HDL-C

rs2862183

2:122415398

CLASP1

T/C

0.22

76,674

154,118

0.014

0.003

7.5E−9

3.6E−7

 HDL-C

rs295849

17:35161748

LHX1

T/G

0.38

78,288

160,924

0.009

0.002

2.7E−8

6.8E−7

 HDL-C

rs141588480

20:32013913

SNTA1

Ins/Del

0.95

8,694

18,585

0.054

0.010

2.0E−8

6.1E−7

Loci identified through joint test for SNP main effect and SNP × physical activity interaction

 LDL-C

rs190748049

7:146418260

CNTNAP2

C/T

0.95

14,912

28,715

−7.2

1.5

1.6E−6

4.2E−8

  1. All loci were identified in the meta-analyses of all ancestries combined. HDL-C was natural logarithmically transformed, whereas LDL-C was not transformed. The P values are two-sided and were obtained using a meta-analysis of linear regression model results. EA effect allele, EAF effect allele frequency, OA other allele, betaINT effect size for interaction with physical activity (=the change in logarithmically transformed HDL-C or untransformed LDL-C levels in the active group as compared to the inactive group per each effect allele), seINT standard error for interaction with physical activity
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