Table 1 Directional effect of genetically determined gene expression on disease risk for predicted target genes of breast cancer sentinel risk variants

From: Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Directional effect

Predicted target genes of breast cancer sentinel risk variants

Decreased expression associated with decreased risk

AC007283.5, AHRR, AP006621.5, AP006621.6, APOBEC3B-AS1, ARRDC3, ASCC2, BCL2L15, BTN2A1, CCDC170, CCDC91, CDCA7L, CEND1, CES1, COX11, CTB-161K23.1, CTD-2116F7.1, CYP51A1, DDA1, DFFA, EFEMP2, ENPP7, FAM175A, GATAD2A, HAPLN4, HCG11, HIST1H4L, KCNN4, LRRC25, LRRD1, OGFOD1, PIDD1, PPIL3, PTPN22, RPS23, SIRT5, SMG9, TGFBR2, TM6SF2, TMEM184B, TNS1, ZBTB38, ZNF703

Increased expression associated with decreased risk

AC010335.1, AKAP9, APOBEC3A, ATF7IP, ATG10, ATP6AP1L, BTN2A3P, CBX6, CENPO, CFL1, COQ5, CTD-3137H5.1, DCLRE1B, DNAJC27, ELL, ESR1, HLF, L3MBTL3, NUDT17, PGPEP1, RCCD1, RHBDD3, RNF115, RP11-486M23.2, SIVA1, SYNE1, TEFM, TLR1

Ambiguous

ADCY3, AMFR, APOBEC3B, CCDC127, HSPA4, MRPS18C

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