Fig. 2

DMRs between B6 (n = 6) and C3 (n = 6) parental animals, identified by DSS. a Genome browser view of example B6 > C3 DMR (red) and C3 > B6 DMR (green). b Distribution of DMR size, N = 6380. c Distribution of distance between DMR and nearest TSS (based on RefSeq gene models as of Feb 8, 2016), N = 6380. d Distribution of methylation level in DSS DMRs, by strain and DMR polarity. N = 3166 B6 > C3 DMRs and 3214 C3 > B6 DMRs. The box depicts the 25th to 75th percentiles (color by genotype where B6 is red and C3 is green), the black dot is the median, the whiskers extend to data points up to 1.5*IQR beyond the box, and open gray circles are data points outside the whisker range. e Distribution of CpG density at DSS DMRs (N = 6380), compared to size-matched random genomic regions (N = 6380). f Overlap of DSS DMRs (N = 6380) with DNase hypersensitive sites (UCSC Genome Browser) and H3K4me1 enriched regions (ENCODE peaks ENCFF001XXZ), compared to the average overlap observed for 1000 iterations of size-matched random genomic regions