Fig. 4

Rearrangements t(4;9)(q13;q31) in AciCCs juxtapose the NR4A3 gene locus proximal to active enhancers and NR4A3 binding sites. Detailed presentation of active (H3K27ac, H3K4me3) and repressive (H3K27me3) histone marks, NR4A3 binding sites, CTCF binding sites, and DNA methylation levels in normal parotid gland (a) and three distinct AciCC tumor samples AciCC3 (b), AciCC1 (c) and AciCC2 (d). For each ChIP-seq experiment, ChIP signals (barcharts) as well as corresponding peaks (directly below ChIP signals) are shown. For H3K27ac, the super-enhancer peaks are shown in addition (purple). Furthermore, CTCF motifs within CTCF peaks are shown (below CTCF peaks). Blue arrows indicate motifs on the forward strand, whereas red arrows indicate motifs on the reverse strand. The DNA methylation tracks show the average methylation within 1 kb binned regions