Fig. 1

Structure of Pol2_CORE P301R. a Overview of the Pol ε structure with the defined domains. The P-domain is not visible from this view as it is located on the other side of the structure. The position of the polymerase active site and exonuclease active site is indicated with a blue and green sphere, respectively. b Superimposition of the Pol2_CORE P301R structure (yellow sticks) on the previously published Pol ε structure (4m8o[https://www.rcsb.org/structure/4m8o]²⁶) (blue sticks). The incoming nucleotide at the polymerase site is stabilized by the metal in the B-site, K824, R781 and K785 from the finger domain. R988 and K967 stabilize the 3´-end of the DNA in the polymerase active site²⁸. D877 and D640 are the catalytic residues