Fig. 2 | Nature Communications

Fig. 2

From: Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

Fig. 2

The wild-type and P301R exonuclease active site of Pol ε. a The crystal structure of Pol2CORE-M644G showing the active site of the wild-type exonuclease domain (shown in salmon) with two metals (in dark cyan) and the Exo-loop with P301. Residues mentioned in the main text are shown in cyan. b The structure of the exonuclease domain of Pol2CORE-P301R (shown in light blue) showing the active site and the Exo-loop. The polder omit map calculated for R301 at 5σ is shown as a green mesh. Residues mentioned in the main text are shown in cyan. The metal Ca2+, located in the A-site, is shown in dark cyan

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