Fig. 8
From: Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation
Proposed model of Chi3l3-induced oligodendrogenesis. In the central nervous system, Chi3l3 is expressed and secreted by alternatively activated myeloid cells (MC), including resident microglia and infiltrating macrophages. These cells are located in the corpus callosum (CC) and in close proximity to the subventricular zone (SVZ) of the lateral ventricle (LV). Chi3l3 binds to epidermal growth factor receptor (EGFR) on the surface of endogenous neural stem cells (NSCs) and activates MEK/ERK signaling and a pro-oligodendrogenic transcription factor pattern in a Pyk2-dependent manner, leading to oligodendrogenesis
