Fig. 7 | Nature Communications

Fig. 7

From: Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit

Fig. 7The alt text for this image may have been generated using AI.

A model of the interaction between Lola29M and Fru in shaping the sexual dimorphism of mAL neurons and fly sexual behavior. Female neurons (left-hand side) lack FruBM, and consequently Lola29F is produced in sufficient abundance to impede the masculinizing action of Lola29M, leading to the production of mAL neurons without the ipsilateral neurite. Male neurons (right-hand side) express FruBM, which forms a complex with Lola29M and represses proteolysis of Lola29M. This results in the accumulation of Lola29M, which induces the ipsilateral neurite in some mAL neurons via robo1 repression

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