Fig. 4 | Nature Communications

Fig. 4

From: Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

Fig. 4

mPFC Drd2-expressing cells are not necessary for the ketamine response. a Representative AAV-hM4Di viral expression in ventral mPFC. b Forced swim immobility time 24 h after hM4Di inhibition and ketamine (post-hoc t-test, p < 0.001). c Time to feed in novelty suppressed feeding test 72 h after photoinhibition and ketamine administration (Mantel–Cox (log rank) overall p < 0.0001, WT-veh vs. WT-ket p < 0.0001, Cre-veh vs. Cre-ket p < 0.05). n = 5 males, 2 females per WT group, n = 4 males, 3 females per Cre group; *p < 0.05, ***p < 0.001. Error bars represent mean ± SEM, scale bar 100 µM. Male—closed data points, female—open data points

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