Table 3 Simulated malaria incidence in children given DHA-PQ seasonal malaria chemoprevention, following the WHO 2010 and 2015 dosing recommendations

From: Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children

 

Dosing regimen (WHO 2010)

Increased dosing regimen (WHO 2015)

Relative reduction (%)

Malaria incidence (%) at day 60, a single treatment

33.0 (24.0–43.3)

22.5 (17.5–34.5)

32.3

Malaria incidence (%) at day 120, three months of SMC

27.0 (14.5–45.0)

16.5 (9.00–26.0)

38.8

Malaria incidence (%) at day 90, three months of SMC

12.0 (4.23–27.0)

5.00 (1.50–10.5)

58.3

Malaria incidence (%) at day 120, four months of SMC

13.0 (0.40–30.0)

5.50 (1.50–11.5)

57.6

  1. All values are reported as median (95% confidence interval) unless otherwise specified
  2. SMC seasonal malaria chemoprevention, WHO World Health Organization
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