Fig. 8
From: Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
A proposed model of Usp7 deubiquitinating Yorkie (Yki). When Hippo (Hpo) pathway turns on, Hpo phosphorylates and activates Wts. In turn, Wts phosphorylates the transcriptional coactivator Yki, culminating Yki retention in the cytoplasm via binding with 14-3-3. When Hpo pathway is closed, Yki translocates into the nucleus to activate the target gene expression with the assistance of Sd. The nuclear Yki protein is destabilized by proteasome, which is attenuated by Usp7
