Fig. 6 | Nature Communications

Fig. 6

From: Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

Fig. 6

Effect of reversion mutations on neutralization potency and breadth. a Antibody neutralization of the wild-type and reversion mutants of the CH103 lineage intermediate I4 and the CH103 bnAb against autologous and heterologous Env-pseudoviruses. b Antibody neutralization of the wild-type and reversion mutants of the DH270 lineage intermediate I2 and the DH270.2 bnAb against autologous and heterologous Env-pseudoviruses. Antibody neutralization was measured by a TZM-bl cell-based assay using a select panel of geographically and genetically diverse Env-pseudoviruses. All values are IC50 (µg/mL) unless otherwise noted

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