Table 2 Results of pharmacokinetic parameters of TB47 in BALB/c mice
Drug delivering | Parameters | Unit | Mean | SD |
|---|---|---|---|---|
Intravenous injection | AUC(0-t) | μg L−1 × h | 10,409 | 139 |
|  | AUC(0-∞) | μg L−1 × h | 11,951 | 565 |
| Â | MRT(0-t) | h | 14.7 | 1.7 |
|  | MRT(0-∞) | h | 22.3 | 3.7 |
| Â | t 1/2z | h | 17.7 | 2.6 |
|  | CL | L h−1 kg−1 | 0.17 | 0.01 |
|  | V | L kg−1 | 4.27 | 0.44 |
|  | C 2min | μg L−1 | 3709 | 1805 |
Oral administration | AUC(0-t) | μg L−1 × h | 19,823 | 1665 |
|  | AUC(0-∞) | μg L−1 × h | 33,144 | 5164 |
| Â | MRT(0-t) | h | 20.2 | 0.3 |
|  | MRT(0-∞) | h | 52.0 | 4.2 |
| Â | t 1/2z | h | 35.6 | 2.7 |
| Â | T max | h | 3.2 | 2.8 |
|  | CL | L h−1 kg−1 | 0.30 | 0.02 |
|  | V | L kg−1 | 15.49 | 0.38 |
|  | C max | μg L−1 | 626 | 282 |
