Fig. 4 | Nature Communications

Fig. 4

From: Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats

Fig. 4

Dapagliflozin causes ketoacidosis in normal rats through β-1 adrenergic and glucocorticoid activity. a, b Heart rate and body temperature after treatment with dapagliflozin ± atenolol ± mifepristone. c, d Whole-body fatty acid and glycerol turnover. e Liver acetyl-CoA content. f Whole-body glucose turnover. g, h Plasma β-OHB concentrations and β-OHB turnover. i Plasma bicarbonate. In all panels, data are the mean ± S.E.M., with comparisons by ANOVA with Bonferroni’s multiple comparisons test

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