Table 2 Frequency of each antigen being present in the most protective combinations

From: Targets of complement-fixing antibodies in protective immunity against malaria in children

Combination size:

Frequency of antigen in top 1% of combinations

3 antigens

4 antigens

5 antigens

6 antigens

RALP1

100%

100%

100%

100%

MSP7

72.7%

66.7%

65.2%

64.6%

Ripr

36.4%

62.5%

85.8%

99.2%

EBA140RIII-V

18.2%

20.8%

16.8%

18.1%

RH2–2030

18.2%

25.0%

32.9%

39.5%

MSP-DBL1

18.2%

18.8%

29.7%

37.7%

PfRH5

9.1%

18.8%

31.6%

44.4%

GAMA

9.1%

18.8%

16.8%

18.1%

MSP1–19

9.1%

18.8%

19.4%

26.4%

EBA175RII

9.1%

25.0%

32.3%

35.1%

MSP6

0%

8.3%

13.5%

20.4%

EBA175RIII-V

0%

2.1%

6.5%

9.6%

MSP10

0%

0%

3.2%

7.5%

MSP2(3D7)

0%

2.1%

11.0%

15.0%

MSP4

0%

2.1%

5.8%

10.6%

EBA140RII

0%

4.2%

12.3%

17.8%

AMA1

0%

2.1%

8.4%

14.5%

MSP9

0%

0%

0.6%

1.0%

MSP3

0%

4.2%

8.4%

19.9%

Pf113

0%

0%

0%

0.5%

  1. For combinations of antigens of size n ≤ 6, we calculated the PPE of all possible combinations. These were then ranked according to their PPE, and the top 1% of combinations with the highest PPE were analysed to identify which antigens most commonly occurred in the most protective combinations. The table shows the frequency at which each of the antigens were included in the top 1% of protective combinations