Fig. 4

Gene dysregulation in BL. a Cumulative imbalance profile of 37/39 BL cases excluding the physiological rearrangement in IGH, IGK, and IGL loci. The Fig. does not include the cases with polyploid genome (4108627) and without copy number aberrations (4110996). Losses are indicated in blue, gains in orange, and copy neutral losses of heterozygosity (LOH) as red line. b Genes recurrently affected by SNVs, SVs, CNAs, and indels in BL (frequency ≥3 cases). The events in recurrently affected genes are shown independent of the transcript form. The affected genes are ordered by frequency, as well as gene name and the cases are displayed according to the BL subgroups (solBL in gray, leukBL in red, and pleuraBL in orange). The cases are also annotated with MUM1, BCL2, and SOX11 expression status analyzed by immunohistochemistry, as well as MYC translocation status. c Plot contrasting mutational load and replication time of recurrently altered genes in BL. The x axis displays the median replication time in five lymphoblastoid B-cell lines (ENCODE cell lines GM12801, GM06990, GM12812, GM12813, and GM12878) and the y axis the mutation count per gene